Hydronephrosis develops whenever urine flow from the kidney is interrupted. The most frequent cause in adults is a kidney stone lodged in the ureter, the narrow tube between the kidney and the bladder. According to the National Institute of Diabetes and Digestive and Kidney Diseases, roughly 1 in 11 Americans will develop a kidney stone in their lifetime, and ureteral stones are a leading reason patients arrive in emergency rooms with severe flank pain and a backed up kidney.
In men over 50, an enlarged prostate (benign prostatic hyperplasia) is another common driver. The prostate presses on the urethra, urine pools in the bladder, and pressure travels back up to the kidneys. Other causes include ureteral strictures from prior infections or surgery, bladder or pelvic tumors, pregnancy (where the growing uterus compresses the ureters), and neurogenic bladder conditions that prevent the bladder from emptying. In children, hydronephrosis is often congenital, caused by a narrowed ureteropelvic junction or vesicoureteral reflux discovered on prenatal ultrasound.
