Although the exact trigger is not always known, most urologists believe Peyronie's disease begins with small injuries to the penis, often during intercourse, sports, or normal daily activity. In some men the tissue heals normally. In others, the body lays down extra collagen as it repairs the injury, and a firm plaque forms inside the tunica albuginea. That plaque does not stretch the way healthy tissue does, so the penis bends or shortens during erection.
Genetics also play a role. Men with a personal or family history of Dupuytren's contracture, a hand condition that thickens tissue in the palm, are more likely to develop Peyronie's disease. Connective tissue disorders, diabetes, high blood pressure, low testosterone, smoking, and pelvic or prostate surgery have also been linked to higher risk in research summarized by the National Institute of Diabetes and Digestive and Kidney Diseases. Age matters too: the condition is most often diagnosed in men between 40 and 70, though younger men can be affected.
The good news is that understanding the cause is not required to begin treatment. A careful exam, a few measurements, and a focused conversation about your symptoms give us everything we need to start.
