Kidney cancer develops when cells in the kidney undergo genetic mutations that cause them to multiply rapidly. While the exact trigger is not always identifiable, several well-established risk factors can increase a person's likelihood of developing renal cell carcinoma. Smoking doubles the risk compared to non-smokers, and the risk decreases gradually after quitting. Obesity is another significant contributor, as excess body weight alters hormone levels that may promote abnormal cell growth in the kidneys.
Chronic high blood pressure, whether treated or untreated, has been consistently linked to increased kidney cancer incidence. Occupational exposure to certain chemicals, including trichloroethylene and cadmium, also elevates risk. Patients with advanced chronic kidney disease, particularly those on long-term dialysis, face a higher probability of developing cystic changes that can become malignant. Additionally, certain inherited conditions such as Von Hippel-Lindau disease and hereditary papillary renal cell carcinoma carry a substantially increased risk. Men are diagnosed roughly twice as often as women, and incidence is highest among adults aged 55 to 75.
